211672

Nipecotic acid

98%

• Sinónimos: (±)-β-Homoproline, 3-Carboxypiperidine, 3-Piperidinecarboxylic acid, Hexahydronicotinic acid
• Fórmula empírica (notación de Hill): C₆H₁₁NO₂
• Número de CAS: 498-95-3
• Peso molecular: 129.16
• EC Number: 207-873-9
• MDL number: MFCD00005992
• UNSPSC Code: 12352100
• PubChem Substance ID: 24278161
• NACRES: NA.22

Propiedades

• assay: 98%
• form: solid
• mp: 261 °C (dec.) (lit.)
• solubility: water: soluble 50 mg/mL, clear, colorless to faintly yellow
• functional group: carboxylic acid
• SMILES string: OC(=O)C1CCCNC1
• InChI: 1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)
• InChI key: XJLSEXAGTJCILF-UHFFFAOYSA-N
• Gene Information: human ... SLC23A2(9962)

Descripción

General description

R(−)-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices[1]. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy[2].

Application

Nipecotic acid was used in determination of the antiepileptic drug vigabatrin and the amino acid neurotransmitters in rat brain extracellular fluid by capillary electrophoresis with laser-induced fluorescence detection[3].

Reactant for concurrent esterification and N-acteylation of amino acids with orthoesters

Reactant for synthesis of:
Anticonvulsants
HCV NS5B polymerase inhibitors
Cathepsin S inhibitors
Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Positive allosteric modulator of metabotropic glutamate receptor 4

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves