Oxidative damage to DNA bases commonly resultsin the formation of oxidized purines, particularly 7,8-dihydro-8-oxoguanine (8-oxoG) and 7,8-dihydro-8-oxoadenine (8-oxoA), the former being a well-known mutagenic lesion. Since 8-oxoG is readily subject to further oxidation compared with normal bases, the insertion of
Sodium hexachloroiridate injected 1 day after i.p. injection of 10(6) mouse ovarian tumor cells prevents the appearance of ascitic tumors in mice. Mice given injections of tumor cells all die at 20 to 30 days after tumor injection. Mice treated
The aqueous oxidations of glutathione (GSH) by [IrCl(6)](2-), [Fe(bpy)(2)(CN)(2)](+), and [Fe(bpy)(CN)(4)](-) are described. All three reactions are highly susceptible to catalysis by traces of copper ions, but this catalysis can be fully suppressed with suitable chelating agents. The direct oxidation
Journal of the American Chemical Society, 130(12), 3780-3787 (2008-03-07)
In an effort to develop sensitive nanoscale devices for chemical and biological sensing, we have examined, using liquid gating, the conductance of semiconducting single-walled carbon nanotube-based field-effect transistors (SWCNT-FETs) in the presence of redox mediators. As examples, redox couples K3Fe(CN)6/K4Fe(CN)6
Horseradish peroxidase (HRP) was oxidized by IrCl6(2-) to a mixture of compounds I and II, the rate of oxidation and the ratio of the mixture being greatly affected by pH (Hayashi & Yamazaki, 1979). Oxidation of HRP by IrCl6(2-) in
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