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Sigma-Aldrich

6,9-Dichloro-2-methoxyacridine

97%

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About This Item

Fórmula empírica (notación de Hill):
C14H9Cl2NO
Número de CAS:
86-38-4
Peso molecular:
278.13
EC Number:
201-666-7
MDL number:
MFCD00005028
UNSPSC Code:
12352100
PubChem Substance ID:
24848741
NACRES:
NA.22

assay

97%

form

solid

mp

163-165 °C (lit.)

SMILES string

COc1ccc2nc3cc(Cl)ccc3c(Cl)c2c1

InChI

1S/C14H9Cl2NO/c1-18-9-3-5-12-11(7-9)14(16)10-4-2-8(15)6-13(10)17-12/h2-7H,1H3

InChI key

RYRNQWYNHLLOGX-UHFFFAOYSA-N

General description

6,9-Dichloro-2-methoxyacridine on reaction with quinolizidinylalkylamines yields 4-aminoquinoline and 9-aminoacridine derivatives.

Application

6,9-Dichloro-2-methoxyacridine was used in the synthesis of 9-amino-6-chloro-2-methoxyacridine, N′-(6-Chloro-2-methoxy-acridin-9-yl)-heptylamine and N,N′-bis-(6-chloro-2-methoxy-acridin-9-yl)-hexane-1,6-diamine.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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C Boido Canu et al.
Bollettino chimico farmaceutico, 128(6), 212-215 (1989-06-01)
By reacting three quinolizidinylalkylamines with 4,7-dichloroquinoline and 6,9-dichloro-2-methoxyacridine six derivatives of 4-aminoquinoline and 9-aminoacridine were obtained. These compounds, which are of interest as potential antibacterial, antiprotozoarian, anti-helminthic and antitumoral agents, so far have been tested against lymphocytic leukemia P 388
Lucie Guetzoyan et al.
Bioorganic & medicinal chemistry, 17(23), 8032-8039 (2009-11-03)
A series of acridine derivatives were synthesised and their in vitro antimalarial activity was evaluated against one chloroquine-susceptible strain (3D7) and three chloroquine-resistant strains (W2, Bre1 and FCR3) of Plasmodium falciparum. Structure-activity relationship showed that two positives charges as well
Origin of the complex fluorescence emission of 9-amino-6-chloro-2-methoxyacridine. 1. Experiment.
Fan P, et al.
The Journal of Physical Chemistry, 93(18), 6615-6622 (1989)
Ana Gomes et al.
ChemMedChem, 9(2), 305-310 (2014-01-30)
Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order

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