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MilliporeSigma

PRNP

prion protein

Sinónimos:
ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30
Especie:
Human PRNP (5621), Mouse Prnp (19122), Rat Prnp (24686), domestic cat PRNP (493886), chicken PRNP (396452), Horse PRNP (100065904), naked mole-rat Prnp (101710391), cow PRNP (281427), domestic guinea pig Prnp (100714701), sheep PRNP (493887) ...Más
ID UniProtKB:
P04156, O60489, P78446, Q15216, Q15221, Q27H91, Q5QPB4, Q8TBG0
ID del gen:
  • Human(5621) Summary: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
  • Mouse(19122) prion protein
  • Rat(24686) prion protein
  • domestic cat(493886) prion protein
  • chicken(396452) prion protein
  • Horse(100065904) prion protein
  • naked mole-rat(101710391) prion protein
  • cow(281427) prion protein
  • domestic guinea pig(100714701) prion protein
  • sheep(493887) prion protein
  • Domestic Rabbit(100345744) prion protein
  • dog(485783) prion protein

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Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
P13207
Phenazine, 98%,
Especie
human
C8981
Carbamazepine, meets USP testing specifications,
Especie
rat, human
C4024
Carbamazepine, powder,
Especie
rat, human
H1512
Haloperidol, powder,
Especie
human, rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
MAB1562
Anticuerpo anti-proteína priónica, aa 109-112, clon 3F4, clone 3F4, Chemicon®, from mouse,
Reactividad de especies
hamster, human
Aplicación
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
MABN2285M
Anti-Prion Protein Antibody, clone POM1, clone POM1, from mouse,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
MABN2298M
Anti-Prion Protein Antibody, clone POM2, clone POM2, from mouse,
Reactividad de especies
human, mouse
Aplicación
ELISA
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
MAB5424
Anti-Prion Protein Antibody, Chemicon®, from mouse,
Reactividad de especies
bovine, elk, mouse, mule deer, sheep
Aplicación
ELISA
immunohistochemistry
western blot
HPA042754
Anti-PRNP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry

Proteins

Referencia del producto
Descripción
Especie
AG210
Proteína priónica, recombinante, ,
Especie
cow
P3615
Prion Protein Fragment 106-126 Human, ≥90% (HPLC), solid,
Especie
human
P4238
Prion Protein Fragment 106-126 Scrambled Human, ≥85% (HPLC), solid,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU046551
MISSION® esiRNA, targeting human PRNP,
Especie
human