NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Sinónimos:
NEDD4-2, NEDD4.2, RSP5, hNEDD4-2
Especie:
Human NEDD4L (23327), Mouse Nedd4l (83814), Rat Nedd4l (291553), sheep NEDD4L (101122748), Zebrafish nedd4l (559634), domestic guinea pig Nedd4l (100301562), domestic cat NEDD4L (101088369), Horse NEDD4L (100054395), Domestic Rabbit NEDD4L (100353099), cow NEDD4L (510003) ...Más
ID UniProtKB:
ID del gen:
- Human(23327) Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
- Mouse(83814) neural precursor cell expressed, developmentally down-regulated gene 4-like
- Rat(291553) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- sheep(101122748) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- Zebrafish(559634) neural precursor cell expressed, developmentally down-regulated 4-like
- domestic guinea pig(100301562) neural precursor cell expressed, developmentally down-regulated gene 4-like
- domestic cat(101088369) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- Horse(100054395) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- Domestic Rabbit(100353099) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- cow(510003) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- dog(476189) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- naked mole-rat(101715398) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- chicken(374119) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-NEDD4L antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-NEDD4L antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Monoclonal Anti-NEDD4L antibody produced in mouse, clone 1D2, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-NEDD4L Antibody, clone 3W9J2, Rabbit Monoclonal, ,
Reactividad de especies
human
Aplicación
western blot
Anti-Phospho-NEDD4L-S448 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
western blot