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MilliporeSigma

KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

Sinónimos:
KIR1.1, ROMK, ROMK1
Especie:
ID UniProtKB:
ID del gen:
  • Human(3758) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56379) potassium inwardly-rectifying channel, subfamily J, member 1
  • Rat(24521) potassium inwardly-rectifying channel, subfamily J, member 1
  • chicken(428236) potassium inwardly-rectifying channel, subfamily J, member 1
  • Horse(100072580) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic cat(101091140) potassium inwardly-rectifying channel, subfamily J, member 1
  • cow(539250) potassium inwardly-rectifying channel, subfamily J, member 1
  • dog(489285) potassium inwardly-rectifying channel, subfamily J, member 1
  • naked mole-rat(101720253) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic guinea pig(100722828) potassium inwardly-rectifying channel, subfamily J, member 1

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Small Molecule - Activator

Referencia del producto
Descripción
Especie
Diazoxide, ,
Especie
rat, mouse, human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
Cromakalim, ,
Especie
rat
Glyburide, meets USP testing specifications,
Especie
rat, human
Glybenclamide, ≥99% (HPLC),
Especie
rat, human
Chlorpropamide, analytical standard, ≥97%,
Especie
human, mouse
Tolbutamide, analytical standard,
Especie
human, mouse

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-KCNJ1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-KCNJ1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
dog, guinea pig, horse, human, rabbit, rat
Aplicación
western blot
Anti-ROMK antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
Anti-KCNJ1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
Gliclazide, powder, ≥98%,
Especie
human
Glimepiride, ≥98% (HPLC), solid,
Especie
human
Repaglinide, ≥98% (HPLC), solid,
Especie
human
Glipizide, solid,
Especie
human
Glyburide, meets USP testing specifications,
Especie
rat, human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Linopirdine, ≥98% (HPLC),
Especie
rat
VU591, ≥98% (HPLC),
Especie
human
Tertiapin-Q trifluoroacetate salt, ≥97% (HPLC),
Especie
rat, human, mouse
Chlorpropamide, analytical standard, ≥97%,
Especie
human, mouse
Tolbutamide, analytical standard,
Especie
human, mouse

Small Molecule - Ligand

Referencia del producto
Descripción
Especie
Glimepiride, ≥98% (HPLC), solid,
Especie
human
Glipizide, solid,
Especie
human
Glybenclamide, ≥99% (HPLC),
Especie
rat, human
Chlorpropamide, analytical standard, ≥97%,
Especie
human, mouse

Small Molecule - Opener

Referencia del producto
Descripción
Especie
Minoxidil, ≥99% (TLC),
Especie
human
Diazoxide, ,
Especie
rat, mouse, human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human KCNJ1,
Especie
human