INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
Sinónimos:
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN
Especie:
Human INPP5D (3635), Mouse Inpp5d (16331), Rat Inpp5d (54259), chicken INPP5D (424745), Zebrafish inpp5d (559103), naked mole-rat Inpp5d (101711777), domestic guinea pig Inpp5d (100722743), sheep INPP5D (101112941), Horse INPP5D (100064896), cow INPP5D (507329) ...Más
ID UniProtKB:
ID del gen:
- Human(3635) Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(16331) inositol polyphosphate-5-phosphatase D
- Rat(54259) inositol polyphosphate-5-phosphatase D
- chicken(424745) inositol polyphosphate-5-phosphatase, 145kDa
- Zebrafish(559103) inositol polyphosphate-5-phosphatase, 145kDa
- naked mole-rat(101711777) inositol polyphosphate-5-phosphatase, 145kDa
- domestic guinea pig(100722743) inositol polyphosphate-5-phosphatase, 145kDa
- sheep(101112941) inositol polyphosphate-5-phosphatase, 145kDa
- Horse(100064896) inositol polyphosphate-5-phosphatase, 145kDa
- cow(507329) inositol polyphosphate-5-phosphatase, 145kDa
- domestic cat(101100500) inositol polyphosphate-5-phosphatase, 145kDa
- dog(100688270) inositol polyphosphate-5-phosphatase, 145kDa
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-INPP5D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-SHIP1 (pTyr1021) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-SHIP1 Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
esiRNA
Referencia del producto
Descripción
Especie