AKT1
v-akt murine thymoma viral oncogene homolog 1
Sinónimos:
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Especie:
Human AKT1 (207), Mouse Akt1 (11651), Rat Akt1 (24185), cow AKT1 (280991), fruit fly Akt1 (41957), chicken AKT1 (395928), Zebrafish akt1 (101910198), Goat AKT1 (100860904), sheep AKT1 (100294652), dog AKT1 (490878) ...Más
ID UniProtKB:
ID del gen:
- Human(207) Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
- Mouse(11651) thymoma viral proto-oncogene 1
- Rat(24185) v-akt murine thymoma viral oncogene homolog 1
- cow(280991) v-akt murine thymoma viral oncogene homolog 1
- fruit fly(41957) CG4006 gene product from transcript CG4006-RA
- chicken(395928) v-akt murine thymoma viral oncogene homolog 1
- Zebrafish(101910198) v-akt murine thymoma viral oncogene homolog 1
- Goat(100860904) v-akt murine thymoma viral oncogene homolog 1
- sheep(100294652) v-akt murine thymoma viral oncogene homolog 1
- dog(490878) v-akt murine thymoma viral oncogene homolog 1
- domestic guinea pig(100714724) v-akt murine thymoma viral oncogene homolog 1
- sheep(101104184) v-akt murine thymoma viral oncogene homolog 1
- domestic cat(101087931) v-akt murine thymoma viral oncogene homolog 1
- naked mole-rat(101700695) v-akt murine thymoma viral oncogene homolog 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Referencia del producto
Descripción
Especie
Phospho-Akt (pSer473) ELISA Kit, for detection of human, mouse or rat phospho-akt (pSer473) in cell and tissue lysates,
Especie
human
Phospho-Akt (pSer473) / pan-Akt ELISA Kit, for detection of human, mouse or rat phospho-akt (pSer473) and pan-akt in cell and tissue lysates,
Especie
human
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Alexa Fluor™ 488, clone SKB1, Upstate®, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
flow cytometry
immunocytochemistry
immunofluorescence
western blot
immunocytochemistry
immunofluorescence
western blot
Anti-AKT antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
Anti-phospho-AKT1 (pThr308) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Akt/PKB Antibody, PH Domain, clone SKB1, clone SKB1, Upstate®, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot
Anti-Phospho-akt (ser473) antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM251, purified immunoglobulin,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Cell Lines
Referencia del producto
Descripción
Especie
Small Molecule - Inhibitor
Referencia del producto
Descripción
Especie
Proteins
Referencia del producto
Descripción
Especie
Akt1/PKBα Protein, active, 15 µg, Active, recombinant full-length human Akt1, containing N-terminal His6 tag, for use in IP-Kinase Assays & Kinase Assays.,
Especie
human
Akt1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
Especie
human
AKT1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
SILu™Prot AKT1,RAC-alpha serine/threonine-protein kinase human, recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C- and 15N-labeled,
Especie
human