- Therapeutic effects of protein kinase N3 small interfering RNA and doxorubicin combination therapy on liver and lung metastases.
Therapeutic effects of protein kinase N3 small interfering RNA and doxorubicin combination therapy on liver and lung metastases.
Oncology letters (2017-11-04)
Yoshiyuki Hattori, Takuto Kikuchi, Mari Nakamura, Kei-Ichi Ozaki, Hiraku Onishi
PMID29098022
ABSTRACT
It has been reported that suppression of protein kinase N3 (PKN3) expression in vascular and lymphatic endothelial cells results in the inhibition of tumor progression and lymph node metastasis formation. The present study investigated whether combination therapy of small interfering RNA (siRNA) against PKN3 and doxorubicin (DXR) could increase therapeutic efficacy against liver and lung metastases.
MATERIALS