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  • Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.

Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.

Autism research : official journal of the International Society for Autism Research (2016-08-06)
Thomas C Jaramillo, Haley E Speed, Zhong Xuan, Jeremy M Reimers, Christine Ochoa Escamilla, Travis P Weaver, Shunan Liu, Irina Filonova, Craig M Powell
PMID27492494
ABSTRACT

Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in Shank3 (Shank3