- Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts.
Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts.
Organic letters (2013-01-18)
Matthew A Perry, Jonathan V Trinidad, Scott D Rychnovsky
PMID23323958
ABSTRACT
A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.
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