- Ruthenium-catalyzed cycloaddition of alkynes and organic azides.
Ruthenium-catalyzed cycloaddition of alkynes and organic azides.
Journal of the American Chemical Society (2005-11-17)
Li Zhang, Xinguo Chen, Peng Xue, Herman H Y Sun, Ian D Williams, K Barry Sharpless, Valery V Fokin, Guochen Jia
PMID16287266
ABSTRACT
Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.
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