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  • Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Bioorganic & medicinal chemistry letters (2001-04-11)
S L Gwaltney, H M Imade, K J Barr, Q Li, L Gehrke, R B Credo, R B Warner, J Y Lee, P Kovar, J Wang, M A Nukkala, N A Zielinski, D Frost, S C Ng, H L Sham
ABSTRACT

Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.