- Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.
Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.
Bioorganic & medicinal chemistry letters (2001-11-27)
S Padmanabhan, R C Lavin, P M Thakker, J Guo, L Zhang, D Moore, M E Perlman, C Kirk, D Daly, K J Burke-Howie, T Wolcott, S Chari, D Berlove, J B Fischer, W F Holt, G J Durant, R N McBurney
PMID11720863
ABSTRACT
Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.
MATERIALS