Skip to Content

Iron homeostasis in breast cancer.

Iron homeostasis in breast cancer.

Cancer letters (2014-02-04)

Oriana Marques, Berta Martins da Silva, Graça Porto, Carlos Lopes

ABSTRACT

Iron is an essential element and a critical component of molecules involved in energy production, cell cycle and intermediate metabolism. However, the same characteristic chemistry that makes it so biologically versatile may lead to iron-associated toxicity as a consequence of increased oxidative stress. The fact that free iron accumulates with age and generates ROS led to the hypothesis that it could be involved in the etiogenesis of several chronic diseases. Iron has been consistently linked to carcinogenesis, either through persistent failure in the redox balance or due to its critical role in cellular proliferation. Several reports have given evidence that alterations in the import, export and storage of cellular iron may contribute to breast cancer development, behavior and recurrence. In this review, we summarize the basic mechanisms of systemic and cellular iron regulation and highlight the findings that link their deregulation with breast cancer. To conclude, progresses in iron chelation therapy in breast cancer, as a tool to fight chemotherapy resistance, are also reviewed.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)

Iron, IRMM^®, certified reference material, 0.5 mm wire

Sigma-Aldrich

Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis

Sigma-Aldrich

Iron, powder, −325 mesh, 97%

Sigma-Aldrich

Iron, chips, 99.98% trace metals basis

Iron, wire reel, 5m, diameter 0.025mm, as drawn, 99.99+%

Iron, wire reel, 1m, diameter 0.5mm, as drawn, 99.998%

Iron, wire reel, 0.5m, diameter 0.25mm, hard, 99.99+%

Iron, wire reel, 0.5m, diameter 1.0mm, as drawn, 99.99+%

Iron, wire reel, 5m, diameter 0.25mm, hard, 99.99+%

Iron, wire reel, 50m, diameter 0.5mm, as drawn, 99.95%

Iron, wire reel, 0.05m, diameter 0.5mm, as drawn, 99.998%

Iron, rod, 500mm, diameter 12.7mm, as drawn, 99.95%

Iron, foil, 50x50mm, thickness 2mm, as rolled, 99.99+%

Iron, tube, 200mm, outside diameter 4.0mm, inside diameter 3.6mm, wall thickness 0.2mm, as drawn, 99.5%

Iron, rod, 200mm, diameter 25mm, as drawn, 98+%

Iron, tube, 100mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%

Iron, foil, 300x300mm, thickness 1.0mm, as rolled, 99.5%

Iron, foil, 300x300mm, thickness 2.0mm, as rolled, armco« soft ingot 99.8%

Iron, wire reel, 1m, diameter 0.025mm, as drawn, 99.99+%

Iron, foil, 300x300mm, thickness 0.15mm, hard, 99.5%

Iron, foil, 50x50mm, thickness 0.25mm, as rolled, 99.99+%

Iron, wire reel, 1000m, diameter 0.125mm, hard, 99.5%

Iron, foil, 10mm disks, thickness 0.005mm, 99.85%

Iron, tube, 500mm, outside diameter 3.18mm, inside diameter 1.96mm, wall thickness 0.61mm, as drawn, 99.5%

Iron, tube, 200mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%

Iron, wire reel, 20m, diameter 0.025mm, as drawn, 99.99+%

Iron, wire reel, 1000m, diameter 0.25mm, hard, 99.5%

Iron, wire reel, 250m, diameter 0.25mm, hard, 99.5%

Iron, tube, 200mm, outside diameter 6.35mm, inside diameter 5.35mm, wall thickness 0.5mm, as drawn, 99.8%