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Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices.

Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices.

Nanomedicine (London, England) (2012-12-22)

Terje Sjöström, Alistair S Brydone, R M Dominic Meek, Matthew J Dalby, Bo Su, Laura E McNamara

ABSTRACT

Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis

Titanium, IRMM^®, certified reference material, 0.5 mm wire

Titanium, IRMM^®, certified reference material, 0.5 mm foil

Sigma-Aldrich

Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis

Sigma-Aldrich

Titanium, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

Sigma-Aldrich

Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

Titanium, wire reel, 200m, diameter 0.25mm, as drawn, 99.6+%

Titanium, wire reel, 5m, diameter 0.5mm, as drawn, 99.6+%

Titanium, wire reel, 5m, diameter 0.25mm, as drawn, 99.99+%

Titanium, tube, 500mm, outside diameter 2.03mm, inside diameter 1.55mm, wall thickness 0.24mm, annealed, 99.6+%

Titanium, wire reel, 1m, diameter 0.25mm, as drawn, 99.99+%

Titanium, wire reel, 20m, diameter 0.05mm, hard, 99.8%

Titanium, wire reel, 2m, diameter 1.0mm, as drawn, 99.99+%

Titanium, wire reel, 200m, diameter 0.125mm, annealed, 99.6+%

Titanium, wire reel, 5m, diameter 1.0mm, as drawn, 99.6+%

Titanium, wire reel, 25m, diameter 0.20mm, annealed, 99.6+%

Titanium, wire reel, 5m, diameter 0.75mm, as drawn, 99.6+%

Titanium, wire reel, 25m, diameter 1.0mm, as drawn, 99.6+%

Titanium, wire reel, 200m, diameter 0.20mm, annealed, 99.6+%

Titanium, wire reel, 20m, diameter 0.125mm, annealed, 99.6+%

Titanium, wire reel, 100m, diameter 1.0mm, annealed, 99.6+%

Titanium, wire, straight, 1000mm, diameter 1.0mm, as drawn, 99.6+%

Titanium, wire reel, 25m, diameter 0.25mm, as drawn, 99.6+%

Titanium, wire reel, 25m, diameter 0.25mm, annealed, 99.6+%

Titanium, wire reel, 200m, diameter 0.25mm, annealed, 99.6+%

Titanium, wire reel, 25m, diameter 1.0mm, annealed, 99.6+%

Titanium, wire reel, 5m, diameter 0.20mm, annealed, 99.6+%