- Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.
Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.
The Journal of antibiotics (1989-09-01)
K Komiyama, S Funayama, Y Anraku, A Mita, Y Takahashi, S Omura, H Shimasaki
PMID2793588
ABSTRACT
Three antioxidant isoflavonoids characterized as 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3) were isolated from the cultured broth of Streptomyces sp. OH-1049. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. In in vitro studies, these antibiotics were found to possess antioxidant activity whereas showed almost no cytocidal activities against HeLa S3 cells.
MATERIALS