Plasma beta-phenylethylamine in Parkinson's disease.

Plasma beta-phenylethylamine in Parkinson's disease.

The Kurume medical journal (2001-02-24)

Y Miura

PMID11197147

ABSTRACT

Plasma beta-phenylethylamine (PEA) levels were determined in 27 patients with Parkinson's disease (PD) in order to evaluate its relation with the severity or clinical course of PD. The plasma PEA concentrations in PD patients were significantly lower (mean +/- SD, 862 +/- 554 pg/ml) than those in the control group (1765 +/- 790 pg/ml) (p < 0.0001). The concentrations of PEA in plasma did not correlate with Hoen and Yahr stage. However, in serial measurements of the PEA of 5 patients in the progressive group of the clinical course of PD, the plasma PEA levels revealed a downward trend after one or two years. On the other hand, in 3 patients of non-progressive group, the plasma PEA remained at the same level. This study suggests that plasma PEA level might reflect nigrostriatal degeneration in patients with PD.

MATERIALS

Product Number

Brand

Product Description

326410

Sigma-Aldrich

Copper, wire, diam. 0.64 mm, 99.995% trace metals basis

433705

Sigma-Aldrich

Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

266515

Sigma-Aldrich

Aluminum, ≤30 μm, spherical powder, ≥99%

326941

Sigma-Aldrich

Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis

518573

Sigma-Aldrich

Aluminum, granular, <1 mm, 99.7% trace metals basis

578002

Sigma-Aldrich

Zinc, nanopowder, 40-60 nm avg. part. size, ≥99% trace metals basis

577995

Sigma-Aldrich

Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

369489

Sigma-Aldrich

Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis

499552

Sigma-Aldrich

Zinc preparation, 5 g/dL Zn⁺² in THF, highly reactive Rieke^®metal

326429

Sigma-Aldrich

Copper, wire, diam. 0.25 mm, 99.999% trace metals basis

349224

Sigma-Aldrich

Copper, wire, diam. 2.0 mm, 99.999% trace metals basis

349410

Sigma-Aldrich

Zinc, foil, thickness 1.0 mm, 99.99% trace metals basis

267651

Sigma-Aldrich

Zirconium, sponge, ≥99% trace metals basis

465666

Sigma-Aldrich

Magnesium, ReagentPlus^®, powder, −325 mesh, 99.5% trace metals basis

267635

Sigma-Aldrich

Zinc, shot, 5 mm, 99.999% trace metals basis

267619

Sigma-Aldrich

Zinc, foil, thickness 0.25 mm, 99.999% trace metals basis

460346

Sigma-Aldrich

Strontium, dendritic pieces, purified by distillation, 99.9% trace metals basis

343730

Sigma-Aldrich

Strontium, random pieces, 99%

356948

Sigma-Aldrich

Tin, foil, thickness 0.127 mm, 99.9%

305812

Sigma-Aldrich

Titanium, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

203823

Sigma-Aldrich

Molybdenum, powder, <150 μm, 99.99% trace metals basis

253987

Sigma-Aldrich

Magnesium, ReagentPlus^®, powder, −50 mesh, ≥99%

266639

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

356891

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

419141

Sigma-Aldrich

Zirconium, foil, thickness 0.1 mm, 99.98% trace metals basis

267902

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

266655

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

266647

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

267724

Sigma-Aldrich

Zirconium, rod, diam. 6.35 mm, ≥99% trace metals basis

510106

Sigma-Aldrich

Tungsten, powder (monocrystalline), 0.6-1 μm, ≥99.9% trace metals basis