- Carcinogenic evaluation of 2,3-dimethyl-2,3-dinitrobutane via the mouse skin bioassay.
Carcinogenic evaluation of 2,3-dimethyl-2,3-dinitrobutane via the mouse skin bioassay.
Journal of applied toxicology : JAT (1994-05-01)
T V Reddy, G R Olson, F B Daniel, M Robinson
PMID8083485
ABSTRACT
Female SENCAR mice initiated with 2,3-dimethyl-2,3-dinitrobutane (DMDNB) and promoted with 12-O-tetradecanoylphorol-13-acetate (TPA) via the SENCAR mouse skin bioassay did not exhibit a significant increase in skin tumors. The mice received 20 mg kg-1 DMDNB divided into six intragastric doses over 2 weeks and were promoted three times per week for 20 weeks.
MATERIALS