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  • A pH gated, glucose-sensitive nanoparticle based on worm-like mesoporous silica for controlled insulin release.

A pH gated, glucose-sensitive nanoparticle based on worm-like mesoporous silica for controlled insulin release.

The journal of physical chemistry. B (2013-03-23)
Lei Sun, Xinge Zhang, Chao Zheng, Zhongming Wu, Chaoxing Li
ABSTRACT

This study prepares a kind of core-shell hybrid nanoparticles, which is worm-like, pH gated, and glucose-sensitive. It has a mesoporous silica nanoparticle (MSN) core and polymer shell (cross-linked and non-cross-linked), bearing 3-acrylamidophenylboronic acid (AAPBA) and N-isopropylacrylamide (NIPAM) as sensor moieties. The shell of the nanoparticles has presented a distinct transition from swollen state to collapsed state as the temperature increases, which offers easy access to drug loading. Here, insulin is applied as a model drug and the behaviors of its loading/release are investigated. Insulin loading is up to 15% via mesoporous silica core. In vitro experiment shows that the cumulative release of insulin is dependent on glucose concentration, and the glucose sensitivity could be adjusted simply by different pH values. Simultaneously, compared with the non-cross-linked shell, the cross-linked shell, using dextran-maleic acid (Dex-Ma) as a macromolecule cross-link, enables insulin to release more persistently. Also, cell viability assay indicates that these nanoparticles have good biocompatibility. Consequently, the novel, pH gated, glucose-sensitive core-shell nanoparticles may have potential applications as a vehicle of self-regulated insulin delivery system.

MATERIALS
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Product Description

Sigma-Aldrich
N-Isopropylacrylamide, ≥99%
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PN-6443-1G1 g
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$156.00
PN-6443-5G5 g
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$468.00
PN-6443-10G10 g
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$780.00
Sigma-Aldrich
Maleic acid sodium salt, ~99%
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PN-6443-1G1 g
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$156.00
PN-6443-5G5 g
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$468.00
PN-6443-10G10 g
Ships in 7 days - from Aldrich Partner.
$780.00
Sigma-Aldrich
N-Isopropylacrylamide, 97%
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SKUVendor SKUPack SizeAvailabilityPriceQuantity
PN-6443-1G1 g
Ships in 7 days - from Aldrich Partner.
$156.00
PN-6443-5G5 g
Ships in 7 days - from Aldrich Partner.
$468.00
PN-6443-10G10 g
Ships in 7 days - from Aldrich Partner.
$780.00
Sigma-Aldrich
Maleic acid, ReagentPlus®, ≥99% (HPLC)
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SKUVendor SKUPack SizeAvailabilityPriceQuantity
PN-6443-1G1 g
Ships in 7 days - from Aldrich Partner.
$156.00
PN-6443-5G5 g
Ships in 7 days - from Aldrich Partner.
$468.00
PN-6443-10G10 g
Ships in 7 days - from Aldrich Partner.
$780.00
Sigma-Aldrich
Sodium maleate dibasic, purum p.a., anhydrous, ≥98.0% (NT)
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SKUVendor SKUPack SizeAvailabilityPriceQuantity
PN-6443-1G1 g
Ships in 7 days - from Aldrich Partner.
$156.00
PN-6443-5G5 g
Ships in 7 days - from Aldrich Partner.
$468.00
PN-6443-10G10 g
Ships in 7 days - from Aldrich Partner.
$780.00
Supelco
Maleic acid, Standard for quantitative NMR, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Sign Into View Organizational & Contract Pricing
SKUVendor SKUPack SizeAvailabilityPriceQuantity
PN-6443-1G1 g
Ships in 7 days - from Aldrich Partner.
$156.00
PN-6443-5G5 g
Ships in 7 days - from Aldrich Partner.
$468.00
PN-6443-10G10 g
Ships in 7 days - from Aldrich Partner.
$780.00