- A novel class of allosteric modulators of AMPA/Kainate receptors.
A novel class of allosteric modulators of AMPA/Kainate receptors.
Bioorganic & medicinal chemistry letters (2009-01-24)
Giuseppe Cannazza, Krzysztof Jozwiak, Carlo Parenti, Daniela Braghiroli, Marina M Carrozzo, Giulia Puia, Gabriele Losi, Mario Baraldi, Wolfgang Lindner, Irving W Wainer
PMID19162477
ABSTRACT
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
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