- Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.
Bioorganic & medicinal chemistry letters (2004-06-19)
Dimitrios Galanakis, Angeliki P Kourounakis, Karyophyllis C Tsiakitzis, Christos Doulgkeris, Eleni A Rekka, Antonios Gavalas, Constantina Kravaritou, Christos Charitos, Panos N Kourounakis
PMID15203134
ABSTRACT
The synthesis and pharmacological evaluation of a series of amide derivatives of NSAIDs with L-cysteine ethyl ester is described. The novel derivatives are potent antiinflammatory, antioxidant and hypocholesterolemic-hypolipidemic agents, while they demonstrate considerably reduced gastrointestinal toxicity. This molecular modification may offer a general route to safer antiinflammatory agents, potentially suitable for chronic use in conditions such as neurodegenerative disorders.
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