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  • An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?

An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?

Journal of medicinal chemistry (1994-11-25)
T R Bailey, G D Diana, J P Mallamo, N Vescio, T L Draper, P M Carabateas, M A Long, V L Giranda, F J Dutko, D C Pevear
ABSTRACT

As a probe of the 3-methylisoxazole portion of our broad-spectrum antipicornaviral series, a panel of 2-acetylfuran analogues was prepared as replacements for the 3-methylisoxazole ring. Comparison of the two series showed remarkable similarity in potency, spectrum of activity, logP, and electrostatic parameters. X-ray studies of 21b bound to human rhinovirus-14 showed that the 2-acetyl group adopted a syn conformation and the carbonyl oxygen acts as a hydrogen bond acceptor with ASN219 in much the same way as the nitrogen of the isoxazole. The importance of the syn conformation and the hydrogen-bonding capability was confirmed by the reduced antiviral activity of the 2-methylfuran and 2-formylfuran analogues. From the results of this study, it is apparent that the syn-2-acetylfuran ring is acting as a bioisostere for the 3-methylisoxazole.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Furyl methyl ketone, natural (US), ≥97%, FG
Sigma-Aldrich
2-Furyl methyl ketone, ≥99%, FG
Sigma-Aldrich
2-Furyl methyl ketone, 99%