Skip to Content
MilliporeSigma

Experimental myringoplasty.

The International journal of artificial organs (1980-11-01)
L Feenstra, B W van der Ven, F E Kohn, J Feijen
ABSTRACT

Artificial eardrums made from biodegradable poly(D,L-lactic acid), poly(glycolic acid) and poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50, and made from the microporous poly(tetrafluoroethylene) and bisphenol-A poly(carbonate) membranes were implanted into the ear and as a reference subcutaneously in rats. The implants were histologically examined for periods up to one year. From the biodegradable polymers studied the poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50 evoked the least tissue reaction and the newly formed tympanic membranes are the best in terms of thickness and overall integrity. The microporous poly(tetrafluoroethylene) membrane can be considered as a valuable support for the formation of a reinforced tympanic membrane.

MATERIALS
Product Number
Brand
Product Description

Supelco
Poly(Bisphenol A carbonate), analytical standard, molecular weight series
Sigma-Aldrich
Poly(Bisphenol A carbonate), average Mw ~45,000 by GPC
Supelco
Poly(Bisphenol A carbonate), analytical standard
Sigma-Aldrich
Poly(Bisphenol A carbonate), melt index 10-12 g/10 min (300°C/1.2kg)