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  • Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.

Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.

Angewandte Chemie (International ed. in English) (2012-11-07)
Amirali Popat, Benjamin P Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, Shi Zhang Qiao
PMID23129230
ABSTRACT

I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.

MATERIALS
Product Number
Brand
Product Description
PHR1087
Supelco
Sulfapyridine melting point standard, Pharmaceutical Secondary Standard; Certified Reference Material
Pricing and availability is not currently available.
S6252
Supelco
Sulfapyridine, ≥99.0%
Pricing and availability is not currently available.
S0883
Sigma-Aldrich
Sulfasalazine, 97.0-101.5%
Pricing and availability is not currently available.
31738
Supelco
Sulfapyridine, VETRANAL®, analytical standard
Pricing and availability is not currently available.