- Preparation of 3,4,5-trisubstituted oxazolones by Pd-catalyzed coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles.
Preparation of 3,4,5-trisubstituted oxazolones by Pd-catalyzed coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles.
The Journal of organic chemistry (2012-10-11)
Zenghui Lu, Weijian Cui, Siyuan Xia, Yihui Bai, Fang Luo, Gangguo Zhu
PMID23046091
ABSTRACT
A novel palladium-catalyzed approach for the assembly of 3,4,5-trisubstituted oxazolones has been achieved by the coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles, which involves an oxidative addition followed by oxypalladation/reductive elimination. The reaction provides a convenient access to diversely substituted oxazolones in satisfactory yields and shows good functional group compatibility.