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  • LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

Autophagy (2012-03-24)
Patricia Gómez-Suaga, Sabine Hilfiker
ABSTRACT

Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.

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Nicotinic acid adenine dinucleotide phosphate sodium salt, ≥92.5%