Skip to Content
MilliporeSigma
  • [Oxazole derivatives as compounds modifying radiation effects in the body of mice].

[Oxazole derivatives as compounds modifying radiation effects in the body of mice].

Radiatsionnaia biologiia, radioecologiia (2012-03-06)
E V Burlakova, F S Dukhovich, E N Gorbatova, V D Gaintseva, G P Zhizhina, T M Zavarykina, E M Molochkina, N P Pal'mina, M A Smotriaeva, Iu A Treshchenkova, L D Fatkullina, L N Shishkina, E L Mal'tseva
ABSTRACT

A new class of substances exhibiting radioprotective and radiosensitizing effects depending on the concentration of the substance has been found. The radioprotective effect is probably due to the resonant absorption of radiation energy and its transformation into low-energy forms, as well as reactions with water radiolysis products. We studied the effects of 2,5-difeniloxazole and di[2-(5-feniloxazolil)]benzene in various concentrations in conjunction with irradiation on the growth of melanoma B-16 in mice and the average time of their lives. When using individual doses of irradiation and doses of preparations, we observed an increase in the average lifetime of mice and a reduced tumor size. These data allow us to conclude about the possibility of using these substances in the radiotherapy of tumors.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,5-Diphenyloxazole, suitable for liquid scintillation spectrometry
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
20 mL
100 mL
In Stock
Details...
$51.90
6 x 20 mL
Estimated to ship on March 21, 2025
$60.60
Sigma-Aldrich
2,5-Diphenyloxazole, 99%, suitable for scintillation
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
20 mL
100 mL
In Stock
Details...
$51.90
6 x 20 mL
Estimated to ship on March 21, 2025
$60.60