- Gold(III) chloride catalysed synthesis of 5-alkylidene-dihydrothiazoles.
Gold(III) chloride catalysed synthesis of 5-alkylidene-dihydrothiazoles.
Organic & biomolecular chemistry (2011-05-17)
Thomas S A Heugebaert, Leander P D Vervaecke, Christian V Stevens
PMID21573285
ABSTRACT
A two step synthesis of dihydrothiazoles is presented. First, the previously unknown N-propargylic dithiocarboimidates are produced in good yields from easily available, cheap starting materials. The subsequent gold catalysed ring closure is fast and efficient, leading to dihydrothiazoles through a cascade of 5-exo-dig cyclisation and 1,3-alkyl migration. The yields range from 74% to 95%.