- "One-pot" multicomponent approach to indolizines and pyrido[1,2-a]indoles.
"One-pot" multicomponent approach to indolizines and pyrido[1,2-a]indoles.
Organic letters (2011-04-23)
Huajian Zhu, Joachim Stöckigt, Yongping Yu, Hongbin Zou
PMID21510619
ABSTRACT
A new synthetic protocol for efficient and regiospecifc assembly of indolizines and pyrido[1,2-a]indoles by coupling of substituted methyl bromides and alkynes with corresponding pyrrole-2-carboxaldehyde and 1H-indole-2-carboxaldehyde has been developed. Additionally, a possible mechanism for the reaction is proposed.
MATERIALS