Nucleophilic heterocyclic carbene as a novel catalyst for cyclopropanation of cyano acrylates.

Nucleophilic heterocyclic carbene as a novel catalyst for cyclopropanation of cyano acrylates.

Organic & biomolecular chemistry (2010-02-06)

Anabha E Raveendran, Rony Rajan Paul, Eringathodi Suresh, Vijay Nair

PMID20135050

ABSTRACT

Nucleophilic heterocyclic carbenes (NHCs) have been used for the first time as catalysts in the cyclopropanation of ethyl cyanocinnamates with phenacyl bromide by Michael-initiated ring-closure (MIRC).

MATERIALS

Product Number

Brand

Product Description

115835

Sigma-Aldrich

2-Bromoacetophenone, 98%

77450

Supelco

2-Bromoacetophenone, for GC derivatization, LiChropur^™, ≥99.0%