- Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil.
Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil.
Organic & biomolecular chemistry (2005-02-11)
Zhouen Zhang, Hiroshi Hatta, Takeo Ito, Sei-ichi Nishimoto
PMID15703793
ABSTRACT
A new family of antitumor prodrugs (1-3) of 5-fluorouracil (5-FU) possessing photolabile 2-nitrobenzyl chromophores have been designed and synthesized to investigate the efficiency and mechanism of photoactivated 5-FU release upon UV-irradiation at lambda(ex)= 365 nm. The photoactivated prodrug 3 derived from conjugation of 2 with a tumor-homing cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) was so designed as to manifest a tumor-targeting function.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
N-Ethyldiisopropylamine solution, suitable for peptide synthesis, ~2 M in 1-methyl-2-pyrrolidinone