- Chromatographic detection of captopril using 4-dimethylaminobenzaldehyde as spray reagent.
Chromatographic detection of captopril using 4-dimethylaminobenzaldehyde as spray reagent.
Bollettino chimico farmaceutico (2001-10-30)
U Ajali, B K Chukwurah
PMID11680093
ABSTRACT
Thin layer chromatographic method, using a mixture of acetone:ethanol in the ratio of 9:1 as a developing solvent system, was used to detect captopril in its formulation. The developed chromatogram was sprayed with 4-dimethylaminobenzaldehyde. The product formed by reaction of captopril with 4-dimethylaminobenzaldehyde gave a yellow colour. Rf of captopril is 0.56.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
4-(Dimethylamino)benzaldehyde, suitable for histochemical demonstration of nitro blue tetrazolium reduction in neutrophils
Sigma-Aldrich
4-(Dimethylamino)benzaldehyde, puriss. p.a., reag. Ph. Eur., ≥99% (perchloric acid titration)