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  • Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases.

Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases.

FEBS letters (1989-04-10)
A D Richards, R Roberts, B M Dunn, M C Graves, J Kay
PMID2651157
ABSTRACT

Inhibitory constants (Ki) between 5 and 35 nM were derived (under different conditions of pH and ionic strength) for the interaction of HIV-1 proteinase with acetyl-pepstatin and H-261, two characteristic inhibitors of aspartic proteinases. Thus this enzyme, essential for replication of the AIDS virus, may be classified unequivocally as belonging to this proteinase family.