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  • CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy.

CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy.

Oncotarget (2016-08-16)
Ilya V Ulasov, Natalya V Kaverina, Dhimankrishna Ghosh, Marya A Baryshnikova, Zaira G Kadagidze, Apollon I Karseladze, Anatoly Y Baryshnikov, Charles S Cobbs
ABSTRACT

Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Anti-Cytomegalovirus Antibody, immediate early, clone 6F8.2, clone 6F8.2, Chemicon®, from mouse