- Facile synthesis of N-(1-alkenyl) derivatives of 2,4-pyrimidinediones.
Facile synthesis of N-(1-alkenyl) derivatives of 2,4-pyrimidinediones.
Nucleosides, nucleotides & nucleic acids (2000-09-22)
U Henriksen
PMID10999249
ABSTRACT
N-(1-alkenyl) derivatives of 2,4-pyrimidinediones (6-9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1-5.
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