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Partners Healthcare
Partners Healthcare
Liquid Visual Tests
Liquid Visual Tests
SMCxPRO™ Immunoassay Instrument and SMC™ Kits
High Sensitivity Protein Measurement at the fg/mL level
Synonym: SMC, Singulex, single molecule counting, xPRO
Pharma Microbiology Method Validation
Our pharma microbiology testing device validation protocols provide correct documentation for audits and with regulatory authorities. When we are on-site, our validation engineers ask the right questions, understand your application, and the validation requirements of your equipment.
Welcome To Achema Pulse 2021
Get your Premium ticket to access Achema Pulse online event:
American College of Veterinary Internal Medicine (ACVIM)
Attend the virtusl American College of Veterinary Internal Medicine (ACVIM) Forum 2021.
Mole Day 2021 Thank You
Mole Day is October 23 (1023), in honor of Avogadro's Number. Solve the chemistry problem below and win an awesome pair of Mole Day socks while supplies last. Coming soon! Save up to 40% on select chemistry products October 18
Cell Culture Freezing Tips
Cell Culture Freezing Tips - Are you following best practices for cryostorage? We have cool tips for protecting your cells.
Baseclick EdU Cell Proliferation Detection Kits: Improve Data Quality and Save Time
Experimental studies measuring cell proliferation have had implications in cancer biology, immunology, cell biology, and developmental biology.
Angiogenesis Assays
Cell based angiogenesis assays to analyze new blood vessel formation for applications of cancer research, tissue regeneration and vascular biology.
Neonicotinoids Pesticides and Metabolites
Neonicotinoids have established themselves as key components in insecticides because of their unique selectivity. The mode of action is similar to nicotine.
Cannabis Testing
Cannabis Testing
Phosphorothioate Oligonucleotides
Phosphorothioate is a widely used backbone variant effective in creating oligonucleotides for antisense knockdowns.
Using Microarray Technology to Select Housekeeping Genes in Chinese Hamster Ovary Cells
In the present study, we have identifi ed species-specifi c housekeeping genes (HKGs) for Chinese Hamster Ovary (CHO) cells using data from microarray gene expression profiling.
pLKO-1 Vector and shRNA Design Frequently Asked Questions
Frequently asked questions about pLKO-1 vector & shRNA design
CRISPR-based Gene Activation
Sigma has developed a gene activation system based on a fusion of dCas9 to the catalytic histone acetyltransferase (HAT) core domain of the human E1A-associated protein p300.
TRC Library Citations
TRC 1.5 human and mouse shRNA libraries
shRNAs for Individual Genes
Find shRNAs for Individual Genes. Over 150,000 pre-cloned shRNA constructs targeting more than 15,000 human and 15,000 mouse genes.
MISSION™ CRISPRa Synergistic Activation Mediator (SAM)
MISSION™ CRISPRa Synergistic Activation Mediator (SAM)
CRISPRi Frequently Asked Questions
FAQs about CRISPRi.
Analysis of Fluorescent Dyes Used for Labeling DNA in Microarray Experiments
An article concerning Analyzing Properties of Fluorescent Dyes for Labeling DNA in Microarray Experiments presented by Sigma-Aldrich.com
siRNA Design, Manufacturing, Transfection & Detection
RNA interference (RNAi) is a natural biological mechanism wherein short inhibitory RNA (siRNA) duplexes induce potent inhibition of gene expression.
Ago RIP to Isolate microRNA and their Targets Using Imprint® RNA Immunoprecipitation Kit
Sigma’s Imprint RNA Immunoprecipitation Kit was used to copurify human argonaute 2 (Ago2)-associated RNAs from HeLa cells. MicroRNAs reverse transcribed and quantitating using Mysticq reagents.
Development of a New Advanced KSOM Mouse Embryo Media that Enables Dual-Use Embryo Culture and Cell Handling Applications
Advanced KSOM mouse embryo media that can be used as a single medium for both harvest and culture of mouse embryos to facilitate creation of transgenic knockout mice.
Technical Bulletins
Technical bulletins for our shRNA products, including Bacterial Glycerol Stock, Purified Plasmid DNA Format, Lentiviral Format, MISSION® Control Vectors, MISSION Control Transduction Particles, MISSION Lentiviral Packaging Mix.
Custom siRNA Duplex Plates
Use our synthetic, small interfering RNA (siRNA) duplex plates to identify gene function, elucidate pathways, and screen for potential new drug targets.
Purification using StrepTrap™ HP 1 mL and 5 mL
This page shows how to purify Strep-tag II recombinant proteins using StrepTrap HP 1 mL and 5 mL from Cytiva.
5'/3' RACE Kit, 2nd Generation Troubleshooting
In addition to the troubleshooting provided in the product manual, most probably the efficiency of the tailing reaction performed by Terminal Transferase could be impaired. This could occur due to several reasons (which will not only affect the control reaction
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