UC455

3-Cyano-7-ethoxycoumarin

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₁₂H₉NO₃
• CAS Number: 117620-77-6
• Molecular Weight: 215.20
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724658
• MDL number: MFCD00467359
• Assay: ≥97% (HPLC)
• Form: solid

Properties

• assay: ≥97% (HPLC)
• form: solid
• color: yellow to orange
• storage temp.: 2-8°C
• SMILES string: CCOc1ccc2C=C(C#N)C(=O)Oc2c1
• InChI: 1S/C12H9NO3/c1-2-15-10-4-3-8-5-9(7-13)12(14)16-11(8)6-10/h3-6H,2H2,1H3
• InChI key: YAFGHMIAFYQSCF-UHFFFAOYSA-N

Description

General description

3-Cyano-7-ethoxycoumarin is a fluorescent substrate for Cytochrome P450 1A1 (CYP1A1), Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2C9 (CYP2C9) and Cytochrome P450 2C19 (CYP2C19).

Application

3-Cyano-7-ethoxycoumarin has been used as a substrate in cytochrome P (CYP) inhibition for fluorescence measurement.

Biochem/physiol Actions

Fluorescent probe useful in microsomal dealkylase studies.

Fluorescent probe useful in microsomal dealkylase studies. Typical drug-drug interactions resulting from enzyme inhibition.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

3-Cyano-7-ethoxycoumarin is soluble in DMSO.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves