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SML2231

Sigma-Aldrich

Erasin

≥98% (HPLC)

Synonym(s):

(E)-N′-((6-(tert-butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide, Erlotinib-resistance antagonizing STAT3 inhibitor

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About This Item

Empirical Formula (Hill Notation):
C20H19N3O3
CAS Number:
2256056-21-8
Molecular Weight:
349.38
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(/C=N/NC(C2=CC=CN=C2)=O)=COC3=CC=C(C(C)(C)C)C=C31

Biochem/physiol Actions

Erasin (Erlotinib-resistance antagonizing STAT3 inhibitor) is a selective inhibitor of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. It was shown to increase the apoptotic rate of HCC-827 cells with acquired resistance against Erlotinib in addition to increasing the apoptotic rate of cultured NSCLC cells in a STAT3-dependent manner.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christian Lis et al.
Scientific reports, 7(1), 17390-17390 (2017-12-14)
Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug development. One of the fundamental challenges of this research field is the broad lack of available lead structures from nature. Here, we demonstrate that modifications

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