S8201

SR-3576

≥98% (HPLC)

• Synonym(s): 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
• Empirical Formula (Hill Notation): C₂₇H₂₇N₅O₅
• CAS Number: 1164153-22-3
• Molecular Weight: 501.53
• NACRES: NA.77
• PubChem Substance ID: 329824599
• UNSPSC Code: 12352200
• MDL number: MFCD18632556
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: light brown to brown
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1cc(NC(=O)c2cccc(c2)-n3cc(NC(=O)Nc4cccc(C)c4)cn3)cc(OC)c1OC
• InChI: 1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
• InChI key: MTFAYLZZDJGFGV-UHFFFAOYSA-N

Description

Application

SR-3576 may be used in JNK3-mediated cell signaling studies.

Biochem/physiol Actions

SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.¹

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable