F2053
Fas Intracellular Domain human
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Synonym(s):
APO-1 interacellular domain, CD95 intracellular domain, Fas IC
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| Size/SKU | Availability | Price |
|---|---|---|
100 μg | Check Cart for Availability | $662.00 |
About This Item
Form:
buffered aqueous solution
Assay:
>90% (SDS-PAGE)
Recombinant:
expressed in E. coli (N-terminal histidine tagged)
Mol wt:
>18.8 kDa
General description
Fas is a key component of apoptosis, and is a cell surface receptor. This gene is localized to human chromosome 10q24.1, and is composed of nine exons and eight introns.[1]
Biochem/physiol Actions
Fas and its ligand play an essential role in apoptosis, by activating the cell death signaling pathway. Mutations in this gene are associated with evasion of apoptosis by cells, leading to tumorigenesis, and prevention of clearance of these cells by the immune system.[1] A polymorphism in this gene results in the production of soluble Fas (sFas), which is implicated in the chronic autoimmune disorder called primary Sjögren′s syndrome (pSS).[2]
Fas intracellular domain, amino acids 191-335, is a widely expressed membrane receptor, which is responsible for controlling tissue homeostasis and immune responses. Fas receptor is activated by Fas ligand causing its trimerization. The aggregated Fas intracellular death domain recruits, via FADD adapter, pro-caspase-8 and forms a DISC (death-inducing signaling complex). Caspase 8, in turn, activates the downstream caspases, such as caspase 3, culminating in apoptosis.
Widely expressed membrane receptor responsible for controlling tissue homeostasis and immune responses.
Physical form
Solution in 50 mM Tris-HCl, pH 8.0, 2 mM EDTA, 2 mM DTT, 300 mM NaCl, 0.05% NP-40, and 10% sucrose.
1 of 1
This Item | |||
|---|---|---|---|
| assay >90% (SDS-PAGE) | assay ≥98% (HPLC), ≥98% (SDS-PAGE) | assay >97% (SDS-PAGE) | assay ≥95% (HPLC), ≥95% (SDS-PAGE) |
| recombinant expressed in E. coli (N-terminal histidine tagged) | recombinant expressed in E. coli | recombinant expressed in baculovirus infected Sf21 cells | recombinant expressed in CHO cells |
| form buffered aqueous solution | form lyophilized | form lyophilized powder | form lyophilized |
| mol wt >18.8 kDa | mol wt 17.6 kDa | mol wt 55 kDa (glycosylated form) | mol wt 17.9 kDa |
| Gene Information human ... FAS(355) | Gene Information human ... FAS(355) | Gene Information mouse ... Fas(14102) | Gene Information human ... FASLG(356) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Storage Class
10 - Combustible liquids
wgk
WGK 1
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