E1407
Monoclonal Anti-Erythropoietin antibody produced in rat
clone 148438, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-EP, Anti-EPO, Anti-Epo
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About This Item
Recommended Products
biological source
rat
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
148438, monoclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
neutralization: suitable
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Epo(13856)
General description
Erythropoietin (Epo) is a pleotropic cytokine that promotes erythropoiesis or proliferation and differentiation of red blood cell precursors. Epo is mainly produced by liver cells in fetal stages, by kidneys under hypoxic conditions; liver and brain also secrete Epo is less amounts. The red blood cell production is stimulated when Epo binds and activates the Epo receptor (EpoR) dimer. EpoR directly regulates the signalling by Jak2, PI3K, NF-κB, STAT5A and STAT5B. Epo also inhibits apoptosis of erythroid progenitors by downregulating Fas and FasL. The expression of Epo is under the control of the transcription factor hypoxia inducible factor (HIF). Erythropoietin exhibits disease-modifying effects in infectious diseases and chronic inflammatory disorders
Monoclonal Anti-Erythropoietin antibody specifically reacts with mouse Erythropoietin.
Monoclonal Anti-Erythropoietin antibody specifically reacts with mouse Erythropoietin.
Immunogen
purified, CHO cell-derived recombinant mouse erythropoietin.
Application
Monoclonal Anti-Erythropoietin antibody is suitable for neutralization reactions.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Stephanie S Watowich
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 59(7), 1067-1072 (2011-02-11)
The process of erythropoiesis in the fetal liver and adult bone marrow is regulated by the hormone erythropoietin (Epo), which is produced in the kidney at low levels under homeostatic conditions. Defects in Epo production result in severe anemia; use
Wolfgang Jelkmann
The Journal of physiology, 589(Pt 6), 1251-1258 (2010-11-17)
The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival, proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly from fibroblasts in the renal cortex. Epo production is controlled at the transcriptional level. Hypoxia attenuates the
Manfred Nairz et al.
Microbes and infection, 14(3), 238-246 (2011-11-19)
Erythropoietin (EPO) is a multi-functional cytokine, which exerts erythropoietic effects but also carries anti-apoptotic and immune-modulatory activities upon binding to two distinct receptors which are expressed on erythroid, parenchymal and immune cells, respectively. Whereas EPO ameliorates hemolytic anemia in malaria
Johannes Vogel et al.
The Journal of physiology, 589(Pt 6), 1259-1264 (2011-02-02)
As the basic function of erythropoietin (Epo) is stimulation of red blood cell production, systemic overexpression of Epo results in erythrocytosis. The patho-physiological consequences of chronically elevated red blood cell counts have been studied in Epo overexpressing mice. Genetically modified
Manfred Nairz et al.
Immunity, 34(1), 61-74 (2011-01-25)
Erythropoietin (EPO) is the principal cytokine regulating erythropoiesis through its receptor, EPOR. Interestingly, EPORs are also found on immune cells with incompletely understood functions. Here, we show that EPO inhibits the induction of proinflammatory genes including tumor necrosis factor (TNF)-α
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