C2247

CPPHA

≥98% (HPLC)

• Synonym(s): N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide, N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• Empirical Formula (Hill Notation): C₂₂H₁₅ClN₂O₄
• CAS Number: 693288-97-0
• Molecular Weight: 406.82
• NACRES: NA.77
• PubChem Substance ID: 329774983
• UNSPSC Code: 12352209
• MDL number: MFCD12912405
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: >20 mg/mL
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• storage temp.: −20°C
• SMILES string: Oc1ccccc1C(=O)Nc2ccc(Cl)cc2CN3C(=O)c4ccccc4C3=O
• InChI: 1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
• InChI key: UFOUABRZSDGGAZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CPPHA is a positive allosteric modulator of mGluR5 receptor.

CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable