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A7433

Sigma-Aldrich

Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C64H106N22O21
CAS Number:
81156-93-6
Molecular Weight:
1519.66
MDL number:
MFCD00076721
UNSPSC Code:
12352200
PubChem Substance ID:
24891234

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O

Gene Information

human ... ALK(238) , BLK(640)
mouse ... ALK(11682) , BLK(12143)
rat ... ALK(266802) , BLK(364403)

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Biochem/physiol Actions

Substrate for protein tyrosine kinase.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
120K5128
049H5816
049H58161
031H58006
031H58005

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J Boonstra et al.
Biochimie, 67(10-11), 1177-1183 (1985-10-01)
Rat pheochromocytoma (PC12) cells contain specific plasma membrane receptors for both epidermal growth factor (EGF) and nerve growth factor (NGF). Whereas EGF addition to PC12 cells causes a persistent enhancement of proliferation. NGF addition induces a transient stimulation of growth
V I Hernández-Ramírez et al.
Experimental parasitology, 95(2), 85-95 (2000-07-27)
Previously, we characterized a 140-kDa protein from Entamoeba histolytica as a beta1-integrin-like molecule that binds fibronectin. In this work we present data showing that the amoebic receptor is associated with another surface molecule, the 220-kDa lectin, and with protein tyrosine
J Goris et al.
The Biochemical journal, 256(3), 1029-1034 (1988-12-15)
By use of the autophosphorylated epidermal-growth-factor receptor and the synthetic peptide RRLIE-DAEY(P)AARG, representing an autophosphorylation site of the transforming protein of Rous-sarcoma virus, it is demonstrated that the phosphotyrosyl phosphatase activity of the polycation-stimulated phosphatases is substantially increased by an
L J Pike et al.
The Journal of biological chemistry, 261(8), 3782-3789 (1986-03-15)
The insulin receptor/kinase was purified to near homogeneity from human placenta. The purified kinase exhibited a specific activity of 300 nmol/min/mg of protein at 30 degrees C using the synthetic peptide, Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, as substrate in the presence of insulin. Treatment
J E Casnellie et al.
Proceedings of the National Academy of Sciences of the United States of America, 79(2), 282-286 (1982-01-01)
The particulate fraction from a lymphoma cell line, LSTRA, was found to contain an apparent high level of tyrosine protein kinase activity. When this fraction was incubated with [gamma-32P]ATP in the presence of 10 mM MnCl2, hydrolyzed, and assayed, 70--80%

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