A6779

Adenosine 5′-triphosphate, periodate oxidized sodium salt

Name: Adenosine 5&#8242;-triphosphate, periodate oxidized sodium salt
Brand: SIGMA
Price: 273 USD

≥97%, bacterial (corynebacterium sp), powder

Synonym(s):

oATP, Adenosine 5′-triphosphate-2′,3′-dialdehyde

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₅O₁₃P₃

CAS Number:

71997-40-5

Molecular Weight:

505.17

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24891137

NACRES:

NA.51

MDL number:

MFCD00056956

Assay:

≥97%

Biological source:

bacterial (corynebacterium sp)

Form:

powder

Storage temp.:

−20°C

Key Documents

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Product Name

Adenosine 5′-triphosphate, periodate oxidized sodium salt, ≥97%

biological source

bacterial (corynebacterium sp)

Quality Level

200

assay

≥97%

form

powder

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)[C@H](O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=O)C=O

InChI

1S/C10H14N5O13P3.Na.H/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/t6-,7+;;/m0../s1

InChI key

IHQATUPGVKMGLT-AUCRBCQYSA-N

Related Categories

Phosphates

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1 of 4

This Item	A6904	A5638	A9376
Sigma-Aldrich A6779 Adenosine 5′-triphosphate, periodate oxidized sodium salt	Sigma-Aldrich A6904 Adenosine 5′-diphosphate, periodate oxidized sodium salt	Sigma-Aldrich A5638 Adenosine 2′,5′-diphosphate sodium salt	Sigma-Aldrich A9376 Adenosine 2′:3′-cyclic monophosphate sodium salt
biological source bacterial (corynebacterium sp)	biological source -	biological source -	biological source synthetic (organic)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
assay ≥97%	assay 90-95%	assay ≥95%	assay ≥93%
form powder	form solid	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

Adenosine 5′-triphosphate 2′,3′ dialdehyde is a derivative of dialdehyde.

Application

Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:

as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
as a nonspecific agonist to assess the activity of P2×₇-R by the mobilization of Ca²⁺
to evaluate the physiological significance of elevated intracellular ATP levels
increased P2rx7 expression for osteoclastogenesis in Flcn-deficient cells

Biochem/physiol Actions

Adenosine 5′-triphosphate 2′,3′ dialdehyde is considered as an inhibitor of P2 × 7 receptor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts.

Daniela Gentile et al.

Frontiers in pharmacology, 8, 638-638 (2017-09-29)

The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection.

William Foulsham et al.

Scientific reports, 9(1), 8617-8617 (2019-06-15)

Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor

Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels.

Ursula Schenk et al.

Science signaling, 1(39), ra6-ra6 (2008-10-02)

T cell receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP released from activated T cells through pannexin-1 hemichannels activated purinergic P2X receptors (P2XRs) to

Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection.

Benjamin H Lee et al.

PloS one, 7(4), e35812-e35812 (2012-05-05)

Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral vectors can induce systemic inflammatory responses. Indeed, overactive host innate immune responses to viral vectors have led to devastating consequences. Macrophages are

Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells

Derangere V, et al.

Cell Death and Differentiation, 21(12), 1914-1914 (2014)

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Global Trade Item Number

SKU	GTIN
A6779-100MG	04061833258439
A6779-25MG	04061833258446

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Adenosine 5′-triphosphate, periodate oxidized sodium salt