SRP6098
GSTP1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
DFN7, FAEES3, GST3, Glutathione S-transferase P, PI
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
27.6 kDa
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... GSTP1(2950)
General description
GSTP1 (glutathione S-transferase P) belongs to the superfamily of glutathione-S-transferases. It is widely expressed and is mainly present in the lung, esophagus and placenta. This gene is mapped to human chromosome 11q13.
Application
GSTP1 human has been used as a standard to measure GST (glutathione S-transferase) activity.
Biochem/physiol Actions
Members of GST (glutathione S-transferase) superfamily are responsible for the metabolism and detoxification various carcinogens, toxins and drugs. GSTP1 can associate with many kinases. Under normal conditions, it associates with c-Jun-N-terminal kinase (JNK) and c-jun. In presence of oxidative or chemical stress, it dissociates from JNK, resulting in its activation. It also associates with peroxiredoxin 1, thereby reactivating it. It interacts with tumor necrosis factor receptor-associated factor 2 (TRAF2). This interaction suppresses TRAF2-associated activation of apoptosis signal-regulating kinase 1, JNK and p38. GSTP1 is also a Cdk5 (cyclin-dependent kinase 5) regulatory protein and determines Cdk5 activity in Alzheimer′s disease brains, as well as in various cancer and neuronal cells. Mutations in the GSTP1 gene might be associated with the severeness of airway dysfunction, treatment outcome of advanced NSCLC (non-small cell lung cancer) in patients and increased risk of OLK (oral leukoplakia).
Physical form
0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 7.0) containing 1 mM EDTA, 0.1 mM PMSF and 30% glycerol.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMPP YTVVYFPVRG RCAALRMLLA DQGQSWKEEV VTVETWQEGS LKASCLYGQL PKFQDGDLTL YQSNTILRHL GRTLGLYGKD QQEAALVDMV NDGVEDLRCK YISLIYTNYE AGKDDYVKAL PGQLKPFETL LSQNQGGKTF IVGDQISFAD YNLLDLLLIH EVLAPGCLDA FPLLSAYVGR LSARPKLKAF LASPEYVNLP INGNGKQ
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Glutathione S-transferase T1, M1 and P1 Genetic Polymorphisms and Susceptibility to Colorectal Cancer in Turkey.
Gorukmez O, et al.
Asian Pacific Journal of Cancer Prevention, 17, 3855-3855 (2016)
The Relationship Between Glutathione S-Transferase-P1 and Beta-2 Adrenoreceptor Genotypes with Asthmatic Patients in the Turkish Population.
Kaymak C, et al.
Genetic Testing and Molecular Biomarkers, 20, 522-522 (2016)
Glutathione S-transferase pi polymorphism contributes to the treatment outcomes of advanced non-small cell lung cancer patients in a Chinese population.
Chen JB, et al.
Genetics and molecular research : GMR, 15, doi: 10-doi: 10 (2016)
Associations Among Glutathione S-Transferase T1, M1, and P1 Polymorphisms and the Risk of Oral Leukoplakia.
He P, et al.
Genetic Testing and Molecular Biomarkers, 20, 312-312 (2016)
Impact of CYP2E1, GSTA1 and GSTP1 gene variants on serum alpha glutathione S-transferase level in patients undergoing anaesthesia.
Mikstacki A, et al.
BMC Medical Genetics, 17, 40-40 (2016)
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