P8624

Pirarubicin

≥95% (HPLC)

• Synonym(s): THP
• Empirical Formula (Hill Notation): C₃₂H₃₇NO₁₂
• CAS Number: 72496-41-4
• Molecular Weight: 627.64
• MDL number: MFCD00869742
• UNSPSC Code: 51281913
• PubChem Substance ID: 329820330
• NACRES: NA.85

Properties

• Quality Level: 200
• assay: ≥95% (HPLC)
• form: powder
• solubility: ethanol: soluble 25 mg/mL
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes; enzyme | inhibits
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](OC6CCCCO6)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C32H37NO12/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40,20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38/h5-7,14,17,19,21-22,31,34,37,39-40H,3-4,8-13,33H2,1-2H3/t14-,17-,19-,21?,22-,31+,32-/m0/s1
• InChI key: KMSKQZKKOZQFFG-NCXNULAVSA-N

Description

Application

Pirarubicin is used to study synergistic cytotoxicity and apoptosis of cancer cells. It is used to study how to protect multi-drug resistance cells from anthracycline induced cytotoxicity.

Biochem/physiol Actions

Pirarubicin, an anthracycline antibiotic that is an analog of doxorubicin, is an antineoplastic drug. Pirarubicin is transported into cells via a sodium-dependent nucleoside transporter.^1,2 It is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.

Packaging

10mg,25mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H350,H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B - Muta. 1B - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable