L9780
Lipase from human pancreas
buffered aqueous solution, ≥250 units/mg protein (Lowry)
Synonym(s):
Triacylglycerol acylhydrolase, Triacylglycerol lipase
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
Recommended Products
form
buffered aqueous solution
specific activity
≥250 units/mg protein (Lowry)
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... PNLIP(5406)
General description
Pancreatic lipase fulfills a key function in dietary fat absorption by hydrolyzing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids.
Application
Lipase has been used in a study to assess the effects of acidification on human milk′s cellular and nutritional content. It has also been used in a study to investigate the effect of physical training on the adipose tissue of diet-induced obesity mice.
Biochem/physiol Actions
The hormone leptin reduces pancreatic secretion and expression of lipase and has been shown to directly inhibit its activity.
Tri-, di-, and monoglycerides are hydrolyzed (in decreasing order of rate).
Unit Definition
One unit will liberate 1.0 μmole of 2-monoglyceride from 1,2-diglyceride per min at pH 8.1 at 37 °C.
Physical form
Solution in 0.1 M Tris containing 0.1 M NaCl and serine protease inhibitor
Analysis Note
Protein determined by Lowry.
Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
The effects of acidification on human milk's cellular and nutritional content
Erickson, T., et al.
Journal of Perinatology : Official Journal of the California Perinatal Association, doi: 10-doi: 10 (2012)
J M de Farias et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 45(3), 190-196 (2012-09-14)
It is well known that high-fat diets (HFDs) induce obesity and result in an increase in oxidative stress in adipose tissue, which leads to an impairment of fat mobilization by a downregulation of the lipases, such as hormone-sensitive lipase (HSL)
Nili Elinson et al.
The British journal of nutrition, 96(4), 691-696 (2006-10-03)
Leptin, a metabolic regulator of energy expenditure, exerts its peripheral effects primarily by altering lipid metabolism. The exocrine pancreas has a key role in the digestion of dietary lipids, but the role of leptin in regulating pancreatic lipases remains unknown.
J Hall et al.
The Journal of small animal practice, 54(5), 275-279 (2013-02-13)
Mushroom toxicosis is rarely diagnosed in dogs and is poorly reported in the veterinary literature. This report suggests that mushroom toxicosis is a potentially under-diagnosed condition in first opinion practice in the UK. Nine dogs with clinical signs consistent with
Minshan Hu et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 21(6), 751-757 (2013-03-05)
Diet induces changes in plasma lipid profiles, and the plasma lipid profiles vary among different genetic backgrounds. The aim of this study was to investigate how a high-carbohydrate (high-CHO) diet interacts with hepatic lipase G-250A promoter polymorphism to affect the
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service