![1,8-Diazabicyclo[5.4.0]undec-7-ene 98%](/deepweb/assets/sigmaaldrich/product/structures/120/564/5b373e23-1624-489c-8efb-692de0f96ffb/640/5b373e23-1624-489c-8efb-692de0f96ffb.png)
This product does not contain a second ribose ring. The structural formula is correct in depicting one ribose ring.
A0752
Adenosine 5′-diphosphoribose sodium salt
≥93%
Synonym(s):
ADPR, ADP-Ribose
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25 MG
$101.00
100 MG
$307.00
500 MG
$1,220.00
About This Item
Empirical Formula (Hill Notation):
C15H23N5O14P2
CAS Number:
Molecular Weight:
559.32
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Recommended Products
biological source
yeast (candida utilis)
Quality Level
assay
≥93%
form
powder
storage temp.
−20°C
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
InChI
1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
InChI key
NWPVXDZLQTURKI-UHFFFAOYSA-N
Related Categories
Application
5′-Deoxy-5′-(methylthio)adenosine has been used:
- to give a range of nicotinamide adenine dinucleotide (NADH)
- oxidation rates for the respiratory complex (CI/CIII/CIV)
- CI/alternative(AOX) pathway[1]
- to measure poly(ADP-ribose) glycohydrolaseactivity[2]
- poly(ADP-ribose) (PAR) binding competition assay[3]
- oxidase (AOX) pathway[1]
- to measure poly(ADP-ribose) glycohydrolase activity[2]
- poly(ADP-ribose) (PAR) binding competition assay[3]
Biochem/physiol Actions
Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na+, Ca2+, and K+ cation channel.[4]
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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