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288144

Sigma-Aldrich

Tricarbonyldichlororuthenium(II) dimer

Synonym(s):

CORM-2

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500 MG
$161.00

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500 MG
$161.00

About This Item

Linear Formula:
[Ru(CO)3Cl2]2
CAS Number:
Molecular Weight:
512.01
MDL number:
UNSPSC Code:
12161600
PubChem Substance ID:
NACRES:
NA.22

$161.00

List Price$175.00Save 8%

In StockDetails


Request a Bulk Order

Quality Level

reaction suitability

core: ruthenium
reagent type: catalyst

SMILES string

[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl

InChI

1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4

InChI key

JYHHJVKGDCZCCL-UHFFFAOYSA-J

Application

Carbon monoxide-releasing molecule used for pharamological studies including:
  • Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
  • Investigations of P2X4 as a possible target
  • Possible modification of thrombus growth or disintegration
  • Enhances fibrinogen as a substrate for thrombin
  • Regulation of ion transport by gasotransmitters

Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines.[1] It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.[2]

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Vance G Nielsen et al.
International journal of molecular sciences, 21(6) (2020-03-22)
Using thrombelastography to gain mechanistic insights, recent investigations have identified enzymes and compounds in Naja and Crotalus species' neurotoxic venoms that are anticoagulant in nature. The neurotoxic venoms of the four extant species of Dendroaspis (the Black and green mambas)
One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes.
Alexakis E, et al.
Tetrahedron Letters, 46(25), 4291-4293 (2005)
Cyclopenta [l] phenanthrenyl and Cyclopenta [a] acenaphthylenyl Half-Sandwich Complexes of Ruthenium as Racemization Catalysts for Secondary Alcohols.
Mavrynsky D, et al.
Organometallics, 28(2), 598-605 (2008)
Vance G Nielsen et al.
Basic & clinical pharmacology & toxicology, 120(2), 207-212 (2016-08-23)
Since the introduction of antivenom administration over a century ago to treat venomous snake bite, it has been the most effective therapy for saving life and limb. However, this treatment is not always effective and not without potential life-threatening side
Michał Majewski et al.
Antioxidants (Basel, Switzerland), 9(2) (2020-02-08)
Alcoholic leaf and petal fractions of Taraxacum officinale (dandelion) were previously demonstrated to exert in vitro antioxidant and antithrombotic activities in blood plasma and platelets. Eight-week-old male Wistar rats (n = 6) were supplemented for four weeks with dandelion fractions

Questions

1–6 of 6 Questions  
  1. How long is TRICARBONYLDICHLORUTHENIUM (II) DIMER stable for when stored in a cool place? Does CO release decrease with long-term storage?

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  2. How long is it stable when stored in a cool place without dissolving?

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  3. How does Tricarbonyldichlororuthenium (II) dimer release CO in vitro? Does it reacts to a specific lightwave or pH?

    1 answer
    1. This product has not been tested for in vivo or in vitro applications. Please see the link below to review a publication that may be helpful:
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604159/

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. What are the potential applications for Product 288144, Tricarbonyldichlororuthenium(II) dimer?

    1 answer
    1. This product has been reported and used as a carbon monoxide releasing agent in biological systems, and a ruthenium catalyst.

      Helpful?

  6. What solvents can be used to dissolve Product 288144, Tricarbonyldichlororuthenium(II) dimer?

    1 answer
    1. This product is slightly soluble in chloroform and dichloromethane. It is also soluble in methanol and tetrahydrofuran, but it forms a solvent adduct.

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